Dr. Issler is interested in understanding the molecular mechanisms mediating major depressive disorder. Her research integrates molecular, behavioral, and bioinformatic approaches to identify the epigenetic processes altered in depression, focusing on the novel class of non-coding RNAs. Dr. Issler performed her graduate studies in the laboratory of Dr. Alon Chen at the Weizmann Institute of Science, where she examined the role of microRNAs (miRNAs), in stress-induced anxiety and depression. Next, she joined the laboratory of Dr. Eric Nestler at Icahn School of Medicine at Mount Sinai for post-doctoral training. There, Dr. Issler studies the role of long noncoding RNAs (lncRNAs) in depression, focusing on their contribution to sex-specific molecular processes.