Dr. Andrew H. Smith earned his B.A. in American Studies from Northwestern University, and his M.D./PhD. from Yale University. His overarching scientific goal is to reduce the need for trial-and-error based decisions in psychiatric care, and his work has been recognized by awards from the International College of Neuropsychopharmacology, the College on Problems of Drug Dependence, and the American Psychiatric Association. An individual NIH National Research Service Award supported his doctoral work in Dr. Joel Gelernter’s laboratory pinpointing novel genomic biomarkers of treatment-response, and the results of this translational research were highlighted by NIDA leadership in congressional hearings on the national opioid crisis. As a physician-scientist track psychiatry resident at the Icahn School of Medicine at Mount Sinai, he has the opportunity to work in the Center for Advanced Circuit Therapeutics founded by Dr. Helen Mayberg, and to benefit from interdisciplinary faculty mentorship provided by Drs. Allison Waters, Martijn Figee, Ki Sueng Choi, and Xiaosi Gu. Currently, he is receiving training in the electrophysiology, neuroimaging, and behavioral methods needed to advance individualized modulation of cortico-subcortical circuits underlying severe compulsive and affective illness.